Hypoglycemic Activity of Inflorescence of Borassus flabellifer Extracts on Blood Glucose Levels of Streptozocin-Induced Diabetic Rats

Evaluation of hypoglycemic activity of inflorescence of Borassus flabellifer extract in male wistar rats has been investigated. Antidiabetic potentials were studies by the orally administration of plant extract at the doses of 150, 300 and 600 mg/kg in streptozocin-induced diabetic male wistar rats. Treatment of streptozocin-induced diabetic male wistar rats with the extracts caused a significant ( p <0.01) reduction in the blood glucose levels when compared with control. The dose of 600 mg/kg showed a significant decrease in blood sugar ( p <0.05) after 2, 4, 6 and 8 hours of extracts administration when compared to control normal saline.  The highest activity resided at the dose of 600 mg/kg with mean percentage glycemic change of 39.50% after 8 hours of extract administration while the other two doses 150 and 300 mg/kg had glycemic change of 30.34% and 31.42% respectively after 8 hours of extract administration. The phytochemical screening revealed the presences of tannins, carbohydrate, terpenes, saponins, flavonoids and alkaloids. This result suggests that the inflorescence of Borassus flabellifer extracts possess antidiabetic effect on streptozocin-induced diabetic male wistar rats.